Can an NP prescribe Oxycodone in Florida?

Yes, but with limits — Florida NPs may prescribe oxycodone when authorized, but oxycodone is Schedule II and Florida generally limits APRN Schedule II prescriptions to a 7-day supply.¹³

That authorization includes the required education, training, experience, and protocol or qualifying autonomous primary-care authority; qualifying graduate education for controlled-substance prescribing; DEA registration; and Florida PDMP review before prescribing unless a statutory exception applies.

For acute pain, a Schedule II opioid prescription is generally capped at 3 days. It may extend to no more than 7 days only if the prescriber determines the longer supply is medically necessary, marks the prescription “ACUTE PAIN EXCEPTION,” and documents the condition and lack of alternatives; nonacute-pain prescriptions must state “NONACUTE PAIN.”²

Florida also requires APRNs prescribing controlled substances for acute pain to follow evaluation, treatment-plan, consent, review, consultation, and recordkeeping standards.⁴ The statutory definition of acute pain excludes cancer, terminal conditions, palliative care, and qualifying severe traumatic injury. The psychiatric-medication exception to the general 7-day Schedule II rule does not apply to oxycodone prescribed for pain.