
Yes — Florida NPs can prescribe semaglutide when they have active Florida APRN licensure, the prescribing is within their specialty, competence, and scope, and they prescribe under an established protocol unless they are acting within qualifying autonomous-practice authority.
Semaglutide is not a controlled substance. Florida APRNs practicing under supervision may prescribe drugs within an established protocol.1
A Florida APRN with qualifying autonomous-practice registration may prescribe semaglutide without a physician protocol only when the prescribing fits Florida’s defined primary-care scope, including family medicine, general pediatrics, or general internal medicine.2 Autonomous registration is not unlimited independent practice; it remains confined to that statutory primary-care scope.2