Can an NP prescribe Vyvanse in California?

Only in narrow circumstances — a California NP may prescribe Vyvanse (lisdexamfetamine), a Schedule II stimulant, only when Schedule II furnishing requirements are met or the NP qualifies under California’s 103/104 independent-practice pathway.¹⁴

For NPs using standardized procedures, the Schedule II drug must be specified in the standardized procedure, and Schedule II or III controlled substances must be furnished or ordered under a patient-specific protocol approved by the treating or supervising physician.¹² The NP also needs an active California NP furnishing number. Schedule II furnishing also requires DEA registration and Schedule II continuing education.³

Qualifying 103/104 NPs may prescribe controlled substances without standardized procedures.⁴ CURES review generally applies before Schedule II-IV controlled-substance prescribing and periodically thereafter unless an exemption applies.⁵ In all cases, prescribing must remain within the NP’s education, training, competence, scope, and any applicable protocols or 103/104 independent-practice authority.