Pennsylvania

Can an NP prescribe Vyvanse in Pennsylvania?

Chris Turitzin
•
Updated
September 1, 2026

Yes — Pennsylvania CRNPs may prescribe Vyvanse (lisdexamfetamine), a Schedule II controlled substance,4 when the prescription is within the CRNP’s specialty and physician collaborative agreement1 and the CRNP has current Pennsylvania prescriptive authority approval, including at least 45 hours of advanced pharmacology coursework.

For this Schedule II medication, the CRNP’s collaborative agreement must identify Schedule II authority, and the prescription may not exceed a 30-day supply.2 CRNPs authorized to prescribe controlled substances must also maintain DEA registration and follow PA PDMP query requirements when they apply.35

CRNPs may not prescribe Schedule I controlled substances, may not delegate prescriptive authority, and this answer does not resolve Schedule V authority.

Citations

  1. 49 Pa. Code §21.283(a); 49 Pa. Code §21.285
  2. 49 Pa. Code §21.284(d)(1)
  3. 49 Pa. Code §21.284b(a)
  4. 35 P.S. §780-104(2)(iii)
  5. Pennsylvania Department of Health PDMP Prescriber Q&A
Chris, founded Single Aim Health in 2024 to provide clinicians, especially NPs and PAs, with essential services for launching and growing their practices. A Stanford graduate in Product Design, Chris co-founded Momentus Media, which was acquired by Facebook, and worked as a Product Manager there. He later gained expertise in digital health through leadership roles at Bicycle Health, Virta Health, and founding Wink Health. Now, he is using his experience to help clinicians through Single Aim Health.
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