Illinois

Can a Illinois NP prescribe medication independently?

Chris Turitzin
Updated
December 9, 2025

In Illinois, a nurse practitioner can prescribe medication independently only after obtaining full practice authority1. Until then, prescriptive authority must be delegated under a written collaborative agreement with a collaborating physician23.

With full practice authority, an APRN may prescribe legend drugs and Schedule II–V controlled substances; however, benzodiazepines or Schedule II narcotics require monthly physician consultation documented in the Prescription Monitoring Program1.

Without full practice authority, prescriptive authority is delegated via the collaborative agreement. Key requirements include:

  • The collaborating physician may delegate non-controlled and controlled prescribing to the APRN3.
  • The APRN must obtain a mid-level practitioner controlled substance license and DEA registration4, and the collaborating physician must also hold an Illinois controlled substances license and DEA registration5.
  • Schedule II delegation is limited and must identify specific drugs by oral/topical/transdermal route, be capped at a 30-day supply with continuation only after prior physician approval, include monthly case discussions, and meet specified education requirements6.
  • The collaborating physician must file notice of delegation with the Department and the PMP7, and all APRN prescriptions must include the collaborating physician’s name8.

Citations

  1. 225 Ill. Comp. Stat. 65/65-43 (a–e)
  2. Ill. Admin. Code tit. 68, § 1300.465(a); Ill. Admin. Code tit. 68, § 1300.440(d)
  3. 225 Ill. Comp. Stat. 65/65-40 (a)
  4. 225 Ill. Comp. Stat. 65/65-40 (b); 720 ILCS 570
  5. Ill. Admin. Code tit. 68, § 1300.430(a)
  6. 225 Ill. Comp. Stat. 65/65-40 (d)(1–5); Ill. Admin. Code tit. 68, § 1300.430(b)(1–5)
  7. 225 Ill. Comp. Stat. 65/65-40 (c)
  8. Ill. Admin. Code tit. 68, § 1300.430(e)
Chris, founded Single Aim Health in 2024 to provide clinicians, especially NPs and PAs, with essential services for launching and growing their practices. A Stanford graduate in Product Design, Chris co-founded Momentus Media, which was acquired by Facebook, and worked as a Product Manager there. He later gained expertise in digital health through leadership roles at Bicycle Health, Virta Health, and founding Wink Health. Now, he is using his experience to help clinicians through Single Aim Health.
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