
A Pennsylvania CRNP cannot prescribe controlled substances without supervision. CRNPs may prescribe controlled substances only when acting in collaboration with a physician under a prescriptive authority collaborative agreement—not independently12. The agreement must also specify physician involvement, including how often the physician will personally see patients3.
When permitted, controlled-substance prescribing is limited to a 30‑day supply for Schedule II and a 90‑day supply for Schedules III–IV, as identified in the agreement4. CRNPs must first obtain DEA registration5, include their NPI on controlled-substance prescriptions6, and may not prescribe Schedule I drugs7; they must also meet minimum evaluation, counseling, and documentation standards for controlled substances8.