
Yes. A North Carolina NP needs a DEA registration to prescribe controlled substances. To prescribe Schedules II–V under a collaborative practice agreement, the NP must have an assigned DEA number and include it on each controlled-substance prescription, and the supervising physician must hold the same or greater schedules1.
Additionally, before prescribing a targeted controlled substance in a pain management setting when therapy will exceed 30 days, the NP must personally consult a supervising physician2; for ongoing therapy, consultation is required at least every 90 days to ensure the prescription remains medically appropriate3.
If an NP prescribes controlled substances, they must also complete at least one hour per year of continuing education focused on controlled-substance prescribing and pain management4.