
Colorado does not set a maximum number of nurse practitioners a physician may supervise. Colorado is a full-practice state where APRNs generally practice independently, so routine physician supervision is not required1.
When an APRN seeks prescriptive authority during the provisional period, a Mentorship Agreement with a physician (or qualified APRN) is required, and the rules outline processes and communication requirements rather than any cap on mentees2. Mentors must meet specific qualifications, including active practice in Colorado and corresponding education and experience5.
The Mentorship Agreement must be mutually structured and documented in writing2, include synchronous, real-time communication3, and APRNs must complete at least 750 hours of mentored prescribing experience before applying for Full Prescriptive Authority4.